COUNTRY STUDY Medicinal products in the Czech Republic Analysis of registered products by ATC code Date: December 30, 2016 ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

CZECH REPUBLIC Number of products per ATC code by registration status Graphics created in IBM Watson ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Approved treatments by ATC code N03AX16 Pregabalin 1190 approved drugs Number of registrations includes all strengths and dosage forms ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Approved treatments by ATC code ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website: Approved Cancelled Nutraceuticals Product after change (6 months) Specific therapeutic program app. Suspended

ALIMENTARY TRACT AND METABOLISM (A) ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Alimentary tract: A01, A02 and A03 Stomatological preparations Acid-related disorders: antacids, gastric-oesophageal reflux, peptic ulcer Drugs for functional GIT disorders: antispasmodics in combination with psycholeptics ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Alimentary tract: A04, A05 and A06 Anti-emetics and antinauseants Bile and liver therapy Drugs for constipation ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Alimentary tract: A07, A08 and A09 Anti-diarrheals, intestinal anti-inflammatory and intestinal anti-infective agents Anti-obesity drugs Digestives, incl. enzymes ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Alimentary tract and metabolism: A10 (drugs used in diabetes) metformin glimepiride ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Alimentary tract and metabolism: A11, A12, A14 Vitamins Anabolic steroids Mineral supplements ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Alimentary tract and metabolism: A16 (other alimentary tract and metabolism products) ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

BLOOD AND BLOOD FORMING ORGANS (B) ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Blood and blood forming organs: B01 (anti-thrombotic agents) clopidogrel ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Blood and blood forming organs: B01 Anti-hemorhagics: anti-fibrinolytics, vitamin K and other hemostatics Anti-anemic preparations: iron, B12, folate, other ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Blood and blood forming organs: B05, B06 Blood substitutes and perfusion solutionsAnti-anemic preparations: iron, B12, folate, other Electrolytes Hypertonic solutions ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

CARDIOVASCULAR SYSTEM (C) ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Cardiovascular: C01, C02 Cardiac glycosides, antiarrhythmic drugs class I and III, cardiac stimulants, vasodilatators for cardiac use, other cardiac preparations Antihypertensives ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Cardiovascular: C03, C04, C05 Vasoprotectives: agents for the treatment of hemorrhoids, anal fissures, and varices, and capillary stabilizing agents Peripheral vasodilatators Diuretics ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Cardiovascular: C07 and C08 Antiarrhythmic drugs: Calcium channel blockers Antiarrhythmic drugs: Betablockers metoprolol bisoprolol carvedilolamlodipine ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Cardiovascular: C09 (ACE inhibitors) Perindopril Ramipril Perindopril + amlodipine Ramipril + amlodipine Losartan Irbesartan Telmisartan Valsartan + diuretics Telmisartan + diuretics ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Cardiovascular: C10 (lipid modifying agents) C10AA HMG CoA reductase inhibitors: C10AA05 – atorvastatin C10AA07 – rosuvastatin ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

DERMATOLOGICALS (D) ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Dermatological agents: D01, D02, D03, D04, D05, D06 Emollients and protectives Antifungals Treatment of wounds and ulcers Antipruiritics Antipsoriatics Antibiotics and topical chemotherapeutics ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Dermatological agents: D07, D08, D09, D10, D11 Corticosteroids for dermal use Antiseptics, disinfectants Medicated dressings Anti-acne preparations Other ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

GENITO-URINARY AGENTS AND SEX HORMONES (G) ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Genito-urinary agents and sex hormones: G01, G02, G03 Gynecological anti-infectives and anti-septics Other gynecological agents Sex hormones G03A – hormonal contraceptives for systemic use ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Genito-urinary agents and sex hormones: G03 Sex hormones and modulators of the genital system: hormonal contraceptives for systemic use androgens, estrogens, progestogens gonadotropins and other ovulation stimulants antiandrogens ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Genito-urinary agents and sex hormones: G04 (urologicals) Solifenacin Sildenafil Tadalafil Tamsulosin Finasteride ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

SYSTEMIC HORMONAL PREPARATIONS (H) ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Systemic hormonal preparations: H Pituitary and hypothalamic hormones and their analogues Corticosteroids for systemic use Thyroid hormones Calcium homeostasis Pancreatic hormones ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

ANTIINFECTIVES FOR SYSTEMIC USE (J) ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Antibacterials for systemic use: J01 J01A – Tetracyclines J01B – Amphenicols J01C – Beta-lactams, penicillines J01D – Other beta-lactams J01E – Sulfonamides and trimetoprim J01F – Macrolides, lincosamides, streptogramines J01G – Aminoglycosides J01M – Quinolones J01R – Combinations J01X – Other Linezolid Amoxicillin + enzyme inhibitor Cefuroxime Clarithromycine ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

J02 – Antimycotics for systemic use J04 – Antimycobacterials J05 – Antivirals Linezolid Antiinfectives for systemic use Fluconazole Voriconazole ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Antiinfectives for systemic use: J06, J07 Immune sera and immunoglobulins Vaccines ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

ANTIINEOPLASTICS AND IMMUNOMODULANTS (L) ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Anti-neoplastic agents: L01 Alkylating agentsAnti-metabolitesPlant alkaloidsCytotoxic antibiotics Methotrexate Bendamustine Capecitabine Temozolomide ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Anti-neoplastic Agents L01X (Other) Imatinib ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Antineoplastic and immunomodulating agents Endocrine (L02) & Immunostimulants (L03) Bicalutanide Anastrozole Letrozole peginterferon alfa-2b filgrastim ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Immunosuppressants: L04 Selective immunosuppressants TNF- ɑ inhibitors Interleukin inhibitors Calcineurin inhibitors Other ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

MUSCULO-SKELETAL SYSTEM (M) ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Musculo-skeletal system: M01, M02, M03 Anti-inflammatory, anti-rheumatic agents Topical muscle and joint pain Muscle relaxants Ibuprofen Diclofenac Etoricoxib Diclofenac ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Musculo-skeletal system: M04, M05, M09 Anti-gout preparations Drugs for the treatment of bone diseases Other drugs for musculo-skeletal disorders ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

NERVOUS SYSTEM (N) ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Nervous system: Anesthetics (N01) and Analgesics (N02) Oxycodone Oxycodone + naloxone Fentanyl Buprenorphine Tramadol TapentadolTramadol + combinations Paracetamol Paracetamol + comb. Sumatriptan ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Nervous system: Anti-epileptics (N03) and Anti-Parkinson drugs (N04) LamotrigineTopiramate Gabapentin Levetiracetam Pregabalin Levodopa + decarboxylase inhibitor + COMT Pramipexole Ropinirole ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Nervous system: Psycholeptics (N05) AntipsychoticsAnxiolyticsHypnotics and sedatives Aripiprazole Quetiapine Olanzapine Risperidone Zolpidem ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Nervous system: N06 Antidepressants Psychostimulants Nootropics Anti-ADHD drugs Anti-dementia drugs AB04 – citalopram AB06 – sertraline AB10 – escitalopram AX11 – mirtazapine AX16 – venlafaxine AX21 – Duloxetine Donepezil Memantine ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Nervous system: N07 Parasympatomimetics Addictive disorders Anti-vertigo drugs Other Nicotine Betahistine ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

ANTIPARASITICS (P) ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Antiparasitics, insecticides and repellents: P ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website: P01 Antiprotozoals P02 Anthelmintics P03 Ectoparasiticides

RESPIRATORY SYSTEM (R) ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Respiratory: R01 and R02 Nasal preparationsThroat preparations ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Respiratory: Drugs for obstructive airway diseases (R03) Montelucast ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Respiratory: R05, R06 and R07 Cough and cold preparations Antihistamines for systemic use Other Levocetirizine Desloratidine ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

SENSORY ORGANS (S) ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Sensory organs: Ophthalmologicals (S01), Otologicals (S02) and combinations (S03) ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

VARIOUS (V) ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Various: V01, V03, V04 and V06 AllergensAll other therapeutic products Diagnostic products General nutrients (nutraceuticals) ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Various: All other non-therapeutic products (V07), Contrast media (V08), and Diagnostic radiopharmaceuticals (V09) ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

Various: Therapeutic radiopharmaceuticals (V10), and all other (V11 and V12) ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website:

ARETE-ZOE, as a consultancy, provides solutions to complex problems in the high stakes and high consequence environment of Global Pharmaceuticals, including clinical research, healthcare informatics, and public health. We blend established, Pharma sector methodologies, innovation, and adaptations/transfers from other sectors to identify and resolve consequential practices that pose risk and often result in avoidable patient casualty. However, we are specifically, not a patient advocacy group but believe in optimizing organizational effectiveness and that smart business is agile, competitive and profitable, while intrinsically safe, secure, and resilient. We work within a global context because transnational interests influence national circumstances and choices at point of prescription. ARETE-ZOE, provides full spectrum organizational and operational risk management consultancy. Our published materials provide a glimpse of some aspects of our services to demonstrate both knowledge and ongoing participation within the Pharmaceutical Industry. Our analysis and consultancy includes all channels of misuse, diversion, counterfeiting and illicit exploitation of pharmaceuticals, medical devices, and precursor chemicals. Our advisement is to manufactures, jurisdictional entities, insurers, legislators, litigators, patients, and health care providers. ​ This scope also frequently segues into the nexus of crime and terrorism as significant influencers that undermine sector integrity differentiated from other criminal activity. Obviously, vulnerability assessment, information collection management and intelligence production supporting decision-making for risk reduction and interventions are routinely within the scope of our services as well as design and implementation of operational control measures. ARETE-ZOE, LLC: 1334 E Chandler Blvd 5A-19, Phoenix, AZ, USA | T: (24/7) | website: